REV-ERB agonist comes up often in conversation and rarely with the context attached. Here we lay out the basics in order, then work through the practical considerations.
Last reviewed on 2026-06-30. Where a claim depends on a specific study, the study is described rather than over-claimed.
Analytical identification and purity assessment often use high-performance liquid chromatography with ultraviolet detection or mass spectrometry. Liquid chromatography–tandem mass spectrometry is used to detect and quantify SR9009 in biological matrices, including urine and blood, for anti-doping or pharmacokinetic studies. Nuclear magnetic resonance spectroscopy can confirm molecular structure. Stability depends on form and storage: the solid is generally more stable than solutions, and repeated freeze–thaw cycles may degrade samples. Purity is typically reported as a percentage from a certificate of analysis.
Regulatory treatment of SR9009 varies by country and context. It is not approved as a therapeutic drug by agencies such as the United States Food and Drug Administration or the European Medicines Agency. Sports authorities list it as a prohibited substance; the World Anti-Doping Agency classifies it among hormone and metabolic modulators. Legal status for personal possession or sale differs across jurisdictions, and some countries may restrict it under analog or research chemical laws. Buyers who seek verified material often rely on independent laboratory testing because online product labels may not match contents.
SR9009 is supplied as a solid research chemical, often in milligram quantities. Laboratories typically weigh it in a controlled environment because fine powders can disperse. Stock solutions are commonly prepared in dimethyl sulfoxide and stored in small aliquots to reduce freeze-thaw cycles. Personal protective equipment and chemical fume hoods are standard when handling unknown or potent compounds. These practices address laboratory safety rather than human use.
Identity and purity of SR9009 samples are usually checked with chromatographic and spectrometric methods. High-performance liquid chromatography can separate the compound from related impurities, while mass spectrometry provides molecular mass confirmation. Nuclear magnetic resonance spectroscopy may be used for structural verification in research settings. No single method proves biological activity, and certificates of analysis should be reviewed alongside raw data. Independent testing is often needed because online products vary widely.
| Property | Value | Notes |
|---|---|---|
| Appearance | White to off-white powder | Common supplier description |
| Solubility | Soluble in DMSO and ethanol | Low solubility in water |
| Typical storage | −20 °C, desiccated, dark | For research samples |
| Analytical method | LC-MS/MS | Used for detection and quantification |
| Regulatory status | Prohibited in sport | WADA metabolic modulator class |
SR9009 binds REV-ERB receptors and alters their repressive activity on target genes. This action can change transcription of genes involved in lipid handling, glucose metabolism, and mitochondrial function. In rodent studies, treated animals have shown changes in muscle oxidative capacity and exercise performance, though effects vary by dose, duration, and model. The precise molecular steps connecting receptor binding to whole-body outcomes are still an active area of investigation. Findings in animals do not automatically translate to humans.
Because REV-ERB receptors are core clock components, SR9009 has been examined for effects on daily rhythms as well as metabolism. Research has explored whether the compound can shift or reinforce circadian gene expression in tissues such as liver and muscle. Some studies report improved metabolic markers in obese or diabetic mice, while others show context-dependent responses. Questions remain about which effects are direct, which are secondary to timing, and how they might differ across species.
SR9009 is a synthetic small molecule studied as an agonist of REV-ERB nuclear receptors. REV-ERB alpha and REV-ERB beta help regulate circadian rhythms and metabolic gene expression. In laboratory research, SR9009 has been used to probe how these receptors affect skeletal muscle, liver, and adipose tissue. The compound was identified in academic drug-discovery work and is often described in scientific literature by its chemical name and research code. It is not an approved medicine, and human clinical data remain limited or absent.
Laboratory identification of SR9009 typically relies on chromatographic separation coupled to mass spectrometry, often with ultraviolet detection as a secondary check. Nuclear magnetic resonance spectroscopy can confirm molecular structure when a reference standard is available. Because many suppliers sell the compound as a research chemical, independent identity testing is important for experimental reproducibility. A single retention time is not sufficient proof of identity, especially when related compounds may be present. Purity assessments usually report a percentage based on area normalization.
SR9009 is generally described as poorly soluble in water and more soluble in organic solvents such as dimethyl sulfoxide and ethanol. Stock solutions are commonly prepared in an organic solvent before dilution into an aqueous buffer or vehicle. Precipitation can occur if the organic fraction is reduced too quickly or if the final concentration exceeds the compound's solubility limit. Sonication or gentle warming may aid dissolution in some protocols, but excessive heat can promote degradation. Container material and pH can also influence observed solubility.
For long-term storage, SR9009 is typically kept as a solid at low temperature, protected from moisture and light. Desiccated conditions limit hydrolysis, while opaque containers reduce photochemical breakdown. Solutions are less stable than solids and are often stored frozen in aliquots to avoid repeated freeze-thaw cycles. Stability data are not standardized across all suppliers, so users should rely on certificate-of-analysis information when available. Degradation may appear as color change, precipitate, or decreased chromatographic purity.
SR9009 is a synthetic small molecule studied as an agonist of the nuclear receptors REV-ERBα and REV-ERBβ. It is not a steroid, peptide, or natural hormone. In scientific literature, it appears under the code SR9009 and in non-scientific contexts as Stenabolic. The compound was identified through chemical screening efforts aimed at targeting circadian clock components. Its status remains investigational, and no regulatory agency has approved it as a human medicine.
REV-ERB proteins help regulate daily cycles in gene expression, including genes tied to lipid and glucose metabolism. SR9009 binds these receptors and alters their activity in cell and animal experiments. Consequences observed in rodents include changes in skeletal muscle oxidative capacity, blood lipid levels, and exercise performance. The precise chain from receptor occupancy to whole-body effects is still an active area of study. Human responses cannot be assumed from rodent data.
Most published work on SR9009 consists of preclinical studies. It is widely sold as a research chemical, a category that does not imply safety, efficacy, or pharmaceutical-grade quality. Sports anti-doping organizations have listed SR9009 as a prohibited substance, and its presence in an athlete sample can lead to sanctions. Legal status differs by country; in several jurisdictions it is not approved for human consumption and may be treated as an unapproved new drug.
Depression, substance use disorders, relationship problems, premenstrual syndrome, and autism were among several psychiatric disorders MDMA assisted therapy was reported to treat. According to psychiatrist George Greer, therapists who used MDMA in their practice were impressed by the results. Anecdotally, MDMA was said to greatly accelerate therapy. According to David Nutt, MDMA was widely used in the western US in couples counseling, and was called empathy. Only later was the term ecstasy used for it, coinciding with rising opposition to its use.
As exciting and promising as Kermani's attempt to ground the belief in revelation in aesthesis and to understand the knowledge of God as a perception of the heart may be, this approach raises the question of how to deal with the sensory experiences of pain and the absence of God in the world. The abysses of suffering in our world —especially with this kind of aesthetic approach to the belief in revelation — compel us to ask how experiences of suffering and salvation, of horror and the beauty of God can be reconciled.
== Biography == In 1993, he immigrated to Canada. Prior to the formation of DVS Sciences. Dr. Baranov, a senior scientist at MDS SCIEX, was a key member of the research team that developed and promoted the Dynamic Reaction Cell®, which remains today at the pinnacle of quadrupole ICP-MS technology. In 2005, together with Scott D. Tanner and Dmitry Bandura, he began independently developing an ICP-TOF-MS based cytometer and became a researcher at the University of Toronto in March 2005. After securing ample funding by 2010 from various sources, including National Institutes of Health, Ontario Institute for Cancer Research (OICR), the Ministry of Research and Innovation, Ontario Centres of Excellence, Health Technology Exchange, and Genome Canada via the Ontario Genomics Institute, and venture capital from 5 AM Ventures, Vladimir and the DVS Sciences team successfully commercialized their technology, leading to the acquisition of DVS Sciences by Fluidigm in 2014 Baranov was a principal scientist at DVS Sciences (and then Fluidigm) developing instrumental concepts and algorithmics that advance the CyTOF® line of products. He also and played a fundamental role in the development of the MaxPar line of metal-labeling reagents until his retirement in 2019.
Sources: en.wikipedia.org
== Finds == The body was identified as that of a person aged about 25 years, who had died in the first half of the 1st century BC. In addition to the sword in its bronze scabbard, a bronze mirror was found, and other grave goods included shield fittings, a sword belt ring, a brooch and a spiral ring (all of copper alloy), and a shattered tin object. All items were of classic celtic design. "There was also evidence for the grave having contained a sheepskin or fleece and woven textile incorporating goat and other animal hairs." The mirror and sword, after conservation, were given to the Isles of Scilly Museum, and as of 2023 are displayed in the museum's visitor centre in the town hall on St Mary's after the closure of the museum's building.
The third and final mission's crew, Skylab 4, set a human endurance record (at the time) with 84 days in orbit when the mission ended on February 8, 1974. Skylab stayed in orbit another five years before reentering the Earth's atmosphere over the Indian Ocean and Western Australia on July 11, 1979. Salyut 4 broke Skylab's occupation record at 92 days. Salyut 6 and Salyut 7 were second-generation stations designed for long duration, and were occupied for 683 and 816 days. Salyut 7 improved upon earlier designs by allowing long-duration crewed missions and more complex experiments. These stations, with their expanded crew capacity and amenities for long term stay, carrying electric stoves, a refrigerator, and constant hot water.
The transport landscape of Pakistan features various modern transit systems. The Orange Line Metro Train in Lahore, inaugurated in 2020, spans 27.1 km (16.8 mi), and includes both elevated and underground sections, accommodating over 250,000 passengers daily. Lahore also boasts the Lahore Metrobus, the first of its kind in Pakistan, operational since February 2013. The Rawalpindi-Islamabad Metrobus, stretching 48.1 km, commenced its first phase in June 2015, with subsequent extensions, and employs e-ticketing and an Intelligent Transportation System. Multan Metrobus, inaugurated in January 2017, serves Multan with its rapid transit services. Peshawar's Bus Rapid Transit, inaugurated in August 2020, marks the fourth BRT system in Pakistan. Karachi's Green Line Metrobus, operational since December 2021, is part of a larger metrobus project financed by the Government of Pakistan and initiated in February 2016. Meanwhile, Faisalabad awaits its proposed rapid transit project, the Faisalabad Metrobus. Karachi Circular Railway, partially revived in November 2020, offers public transit services in the Karachi metropolitan area. Additionally, plans are underway to resurrect Karachi's tramway service, which ceased operations in 1975, in collaboration with Austrian experts. As of 2013, Pakistan boasts approximately 151 airports and airfields, encompassing both military and civilian installations.
=== Systems of the body === Pharmacology can focus on specific systems comprising the body. Divisions related to bodily systems study the effects of drugs in different systems of the body. These include neuropharmacology, in the central and peripheral nervous systems; immunopharmacology in the immune system. Other divisions include cardiovascular, renal, and endocrine pharmacology. Psychopharmacology is the study of the use of drugs that affect the psyche, mind, and behavior (e.g. antidepressants) in treating mental disorders (e.g. depression). It incorporates approaches and techniques from neuropharmacology, animal behavior and behavioral neuroscience, and is interested in the behavioral and neurobiological mechanisms of action of psychoactive drugs. The related field of neuropsychopharmacology focuses on the effects of drugs at the overlap between the nervous system and the psyche. Pharmacometabolomics, also known as pharmacometabolomics, is a field which stems from metabolomics, the quantification and analysis of metabolites produced by the body. It refers to the direct measurement of metabolites in an individual's bodily fluids, in order to predict or evaluate the metabolism of pharmaceutical compounds, and to better understand the pharmacokinetic profile of a drug. Pharmacometabolomics can be applied to measure metabolite levels following the administration of a drug, in order to monitor the effects of the drug on metabolic pathways. Pharmacomicrobiomics studies the effect of microbiome variations on drug disposition, action, and toxicity.
Sources: en.wikipedia.org
== TCI Foundation == TCI Foundation, the social responsibility arm of Transport Corporation of India. The foundation is involved in initiatives related to health, education, women’s development, disability, and disaster relief.
India had a large, consumption-driven middle class and witnessed a communications boom. However, India's economic growth has been accompanied by widening income gaps, gender inequality, and degradation of the environment. In recent years, India has witnessed a shift toward majoritarianism and Hindu nationalism, which has led to democratic erosion.
== History == OpenELIS has early documented implementations in clinical and reference laboratories in Haiti and Côte d'Ivoire. In Côte d'Ivoire, the system has been in routine use since 2009, developed jointly with the country's Ministry of Health and the University of Washington's International Training and Education Center for Health, with funding from the President's Emergency Plan for AIDS Relief (PEPFAR); by 2021 it had been installed in more than 100 laboratories covering HIV, tuberculosis, food and drug safety, and routine testing data. The system was subsequently implemented in other countries, including Vietnam.
Sources: en.wikipedia.org
Legality depends on the country and the intended use. In many places it is sold as a research chemical, but sports and medicine regulations restrict it.
Detection commonly uses liquid chromatography–tandem mass spectrometry. This method can identify the compound in urine or blood at low concentrations.
Typical guidance is −20 °C, dry, and protected from light. Solutions should be aliquoted and limited freeze–thaw cycles should be used.
Laboratories commonly use liquid chromatography coupled with mass spectrometry to detect SR9009. The method can identify the compound and estimate concentration in a sample. Detection limits depend on the matrix and instrument.